A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, ...

Recent research has delved deep into the manifold ways in which diet can affect gut health throughout a person's life. Here ...

The microbe Pyrodictium abyssi is an archaeon—a member of what's known as the third domain of life—and an extremophile. It ...

This study provides useful insights into addressing the question of whether the prevalence of autoimmune disease could be driven by sex differences in the T cell receptor (TCR) repertoire, correlating ...

Biomedical engineers at Duke University have demonstrated a new synthetic approach that turbocharges bacteria into producing more of a specific protein, even proteins that would normally destroy them, ...

High-resolution structures explain the mechanism of human PNPase and provide insights into mutations causing hereditary ...

Detectives often find important clues by digging through rubbish. That approach paid off tremendously for systems biologist Yifat Merbl. When she and her team investigated cellular recycling centres ...

Research shows synthetic chromosomes can be transferred to human cells with potential to improve viral resistance ...

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key repair process called ...

An archaeon reads the same codon in two different ways, overturning a doctrine that has stood for 60 years. Living organisms ...

Cambridge brainpower across a raft of specialisms has been recognised through major funding from the European Union’s Horizon ...